Lipid Regulation and Atherosclerosis

The Role of PCSK9 in the Regulation of LDL-C

Watch the video below, which gives an overview of the role of PCSK9 in cholesterol homeostasis through regulation of low-density lipoprotein receptor (LDLR) degradation.

Associated materials

Download the associated material below relating to the role of PCSK9 in the regulation of LDL-C here.




Atherosclerotic Plaque Vulnerability

View this interactive artery showing the progression of atherosclerosis and plaque vulnerability.


Cholesterol Heat Map

Do you know the low-density lipoprotein cholesterol LDL-C levels of patients with high-risk CVD in your area? View this Cholesterol Heat Map to find out more.


Find a resource to help you empower your ASCVD patients to Aim Low and Stay Low - helping them to reach LDL-C treatment goals and stay there.

LDL-C Action Summit Video

The LDL-C Action Summit is an ongoing initiative among members of the cardiovascular disease community to align around a singular mission to help patients manage LDL-C through a more coordinated effort with the ambition of bending the curve of cardiovascular disease.

Optimizing Lipid Management

Webinar: Guidelines, Discharge Protocol, and Routine Follow-up to Optimize Treatment in Patients With Recent MI

Watch experts discuss current cholesterol guidelines, discharge protocol, and routine follow-up in patients with recent myocardial infarction (MI).

Webinar: Optimizing HCP/Patient Conversation About the Importance of LDL-C Lowering for Patients With Recent MI

Watch experts discuss the healthcare professional (HCP)/patient conversation regarding the importance of LDL-C lowering for patients with recent MI.

Additional Resources – Clinical Practice Recommendations

AHA/ACC/Multisociety 2018 Guideline

Click here to view the American College of Cardiology/American Heart Association Task Force guidelines for the management of blood cholesterol.

ESC/EAS 2019 Guidelines

Click here to view the 2019 European Society of Cardiology and European Atherosclerosis Society Task Force guidelines for the management of dyslipidemia.

AACE/ACE 2020 Consensus Statement

Click here to view the American Association of Clinical Endocrinologists and American College of Endocrinology consensus statement for the management of dyslipidemia and prevention of cardiovascular disease.

2022 ACC Expert Consensus Decision Pathway (ECDP)

Click here to view the American College of Cardiology's ECDP guidance on the role of non-statin therapies for LDL-C lowering in the management of ASCVD risk.

Additional Educational Resources

PDF: The Science and Clinical Management of ASCVD

Download this overview that explains the scientific progression of atherosclerosis and ASCVD, and includes recent clinical guidelines for the treatment of patients with very high-risk ASCVD.